贝宁-科托努地区初治和复治肺结核患者抗结核药物耐药研究
Anti-tuberculosis drug resistance among new and previously treated pulmonary tuberculosis patients in Cotonou,Benin
摘要
目的:评估贝宁最大的结核病中心科托努地区目前抗结核药物的耐药形势。方法:共计分析从肺结核患者分离出的470株结核分枝杆菌复合群:其中244株来自新病人, 226株来自复治病人。使用比例法对分离菌株进行一线药物的敏感性试验。结果:原发耐多药情况与患者的来源有关:若分析所有的患者,则新病人中耐多药相对较高(1.6%);若仅考虑贝宁常住人口,该比例则较低(0.5%),并与1994年国家的耐药监测结果比较。复治患者的耐多药率(11.1%),也与贝宁1994年的耐药监测结果持平。没有发现合并感染人类免疫缺陷病毒与抗结核药物的耐药性相关。结论:本研究表明在流行病学调查中正确的区分患者的重要性,研究人口不同,结果就可能不相同。
出处
《国际结核病与肺部疾病杂志》
2008年第2期69-72,共4页
The International Journal of Tuberculosis and Lung Disease
基金
the staff of the LRM in Cotonou.D Affolabi is supported by a grant from the Directorate Generalfor the Development Cooperation
Brussels
Belgium
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