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巴基斯坦原发性耐多药结核病流行情况

Prevalence of primary multidrug resistance to anti-tuberculosis drugs in Pakistan
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摘要 背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(MDR-TB)问题已十分严重,急需在社区水平对耐多药结核病的严重程度开展评估。本研究为针对巴基斯坦耐药结核病流行状况开展的横段面研究,所使用的痰标本来自于巴基斯坦全国742例未经治疗的新诊断的肺结核患者。目的:评估巴基斯坦原发性耐药的流行情况结果:在672例痰培养阳性患者中,有76例(11.3%)出现了对1种或多种抗结核药物耐药。36例(5.4%)患者对链霉素(10μg/ml)耐药; 51例(7.6%)患者对异烟肼(1μg/ml)耐药;15例(2.2%)患者对利福平(5μg/ml)耐药;12例(1.8%)患者对乙胺丁醇(10μg/ml)耐药;22例(3.3%)患者对吡嗪酰胺耐药。有46例(6.8%)患者痰标本中分离的结核菌株耐1种抗结核药物, 10例(1.5%)同时耐2种抗结核药物,12例(1.8%)同时耐3种抗结核药物,6例(0.9%)同时耐4种抗结核药物,2例(0.3%)同时耐全部5种抗结核一线药。原发性耐多药率为1.8%,(n= 12)(异烟肼1μg/ml,利福平5μg/ml)。结论:研究结果表明,巴基斯坦原发性耐多药率<2%,需要进一步实施有效的DOTS策略。
作者 A.Javaid R.Hasan A.Zafar A.Ghafoor A.J.Pathan A.Rab A.Sadiq C.M.Akram I.Burki K.Shah M.Ansari N.Rizvi S.U.Khan S.R.Awan Z.A.Syed Z.H.lqbal Z.Shaheen N.ur Rehman 邢超
机构地区 Department of Pulmonology Department of Microbiology TB Control Programme Institute of Chest Diseases Department of Pulmonology Oiha Institute of Chest Diseases Gulab Devi Hospital Lyari General Hospital National TB Control Programme Liaqat National Hospital Jinnah Postgraduate Medical Centre King Edwards Medical University Nishtar Medical College Allama Iqbal Medical Wyeth(Pvt) Limited
出处 《国际结核病与肺部疾病杂志》 2008年第2期73-77,共5页 The International Journal of Tuberculosis and Lung Disease
基金 financed by the Wyeth Pharmaceutical (Pvt) Ltd.The sponsor had no role in datacollection data analysis data interpretation or writing of the report.The corresponding author had access to all data in the study and had final responsibility for the decision to submit for publication
关键词 原发性耐药 耐多药结核病 巴基斯坦
分类号 R52 [医药卫生—内科学] R521.05 [医药卫生—内科学]
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参考文献10

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国际结核病与肺部疾病杂志
2008年 第2期

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