摘要
核苷(酸)类似物已成为继干扰素-α之后的又一类用于抗乙型肝炎病毒治疗的有效药物,但是长时间服用核苷(酸)类似物易出现耐药。本文对核苷(酸)类似物耐药的发生机制、耐药后的补救治疗、耐药的预防等内容作一简介,以供临床参考。
Nucleotide analogues have been an another type of effective antiviral drugs besides intefferon-et for treatment hepatitis B, but drug resistance will be developed after long-term therapy. Here, a brief introduction about the mechanism, the rescue therapy and the prevention of drug resistance is presented in this paper for clinical consultation.
出处
《胃肠病学和肝病学杂志》
CAS
2008年第9期771-773,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
乙型肝炎病毒
耐药
Hepatitis B virus
Drug resistance
