高血压患者血清胆红素水平与脂蛋白(a)浓度的临床分析

Level of serum bilirubin and lipoprotein(a)[Lp(a)] of patients with essential hypertension

目的研究高血压患者血清胆红素和脂蛋白(a)[Lp(a)]间的关系,探讨它们在高血压发病机理中的作用。方法78例高血压患者与70例健康对照者,抽空腹静脉血测血脂、血清胆红素。结果和健康对照组比较,高血压患者胆红素水平显著降低(P<0.05),脂蛋白(a)明显高于对照组(P<0.05),并且合并冠心病、脑梗死的高血压患者上述指标差异更为显著(P<0.01)。进行相关分析得到胆红素与LDL和脂蛋白(a)呈负相关(P<0.01)。结论血清胆红素水平与血压之间存在一定相关性,且高血压发病机制可能是通过LDL、Lp(a)而实现的。

Objective： To investigate the relation between serum bilirubin and blood-fat in the patients with essential hypertension, and explore their functions in essential hypertension. Methods： Serum TB, blood-fat and Lp（a） were meas- ured in seventy-eight cases with essential hypertension and seventy healthy controls. Results： Compared with normal con- trol, the hypertension group showed lower（P 〈 0.05） bilirubin, but higher concentrations of LPa（P 〈 0.05 ）. Pearson re- lation analysis showed that bilirubin levels were correlated with Lp（a） and LDL（P 〈 0.05 ）. Conclusion： There is a signif- icant correlation between the bilirubin and essential hypertension. The results sugget tthat bilirubin may play a regulative role through LDL-C and Lp（a） in the development of hypertension.