药物释放环境对层状复合氢氧化物载体的影响

Effects of Drug Release Medium on Layered Double Hydroxide Carrier

以层状复合氢氧化物(LDH)为载体用离子交换法制取乙酰苯甲酸(ASP)的插层复合物LDH-ASP,通过体外释放实验和固相XRD、FT-IR、TEM、TG-DSC及BET-N2比表面积表征,研究了药物释放环境对载体结构的影响.结果表明释放环境pH为4.30-6.89时,载体的层状特征减弱但晶体类型不变;pH为2.48-4.30时,H2PO4-对LDH的嫁接反应引起层状化合物向复杂磷酸盐转化;随环境pH由6.89降低至2.48,载体纯度下降,晶态性征减弱,微孔吸附活性降低.

Layered double hydroxide （LDH） had been used as a cartier of acetylsalicylic acid （ASP） to prepare intercalation compound LDH-ASP via ion exchange reaction. The influence of release medium on the carrier was investigated through extrinsic release test and XRD, FT-IR, TEM, TG-DSC, and BET-N2 surface area characterizations. The results showed that the carder＇s laminar features weakened in a pH range from 4.30 to 6.89, but the LDH crystalclass kept unchanged. In a pH range from 2.48 to 4.30, the probable grating reaction between H2PO4^- and hydroxyls of LDH caused laminar carder transformation into complex phosphates. Along with pH decreased from 6.89 to 2.48, the carrier＇s purity decreased, crystallinity weakened, and micro-pore absorbability declined.