不同临床类型肾综合征出血热患者sICAM-1的动态变化

The dynamic change of soluble intercellular adhension molecule-1(sICAM-1) in different clinical types of patients with hemorrhagic fever with renal syndrome

目的研究不同临床类型肾综合征出血热(HFRS)患者血清可溶性细胞间黏附分子-1(sICAM-1)水平的动态变化,以探讨细胞免疫紊乱在HFRS发病机制中的作用。方法应用酶联免疫检测法(ELISA)对32例HFRS患者病程各期和20例健康人血清sICAM-1水平进行检测。结果HFRS患者血清sICAM-1各期均显著高于对照组,病程极期达高峰,与BUN变化相一致;重症组患者sICAM-1在发病早期和极期均显著高于轻症组。结论细胞免疫功能紊乱在HFRS发病机制中具有重要作用。

Objective To study the dynamic change of soluble intercellular adhension molecule-1（sICAM-1） over clinical course and to explore the role of the disturbance of celluar immune function in the pathogenesis of hemorrhagic fever with renal syndrome. Methods The level of sICAM-1 in srea was detected by double antibody sandwich ELISA method. Results The level of sICAM-1 in patients with HFRS increased significantly in febrile phase, reached its peak in hypotensive and oliguric phase and then decreased gradually in diuretic phase but still higher than that of normal in convalescent phase with valuses being （50. 561±6. 325）, （98. 622 ± 17. 361）, （55.168±7.421） ,and （25. 632±3. 221）pg/mL in different stages,respectively. There existed a positive correlation be tween the level of sICAM-1 and blood urea nitrogen （BUN）. The levels of sICAM-1 in severe group were higher than in light group in different stages. Conclusions The disturbance of celluar immune function may play an important role in the pathogenesis of HFRS.