应用超临界快速膨胀法制备中药丹参SCF-CO_2萃取物超微颗粒

Preparation of micropaticles of SCF-CO_2 extraction of Salvia miltiorrhiza by RESS

目的：应用超临界快速膨胀技术制备中药丹参超临界CO2流体（SCF—CO2）萃取物超微颗粒。方法：将β-环糊精和丹参萃取物按质量8：1混合，对混合物进行RESS制粒；对制得的微粒采用扫描电镜观察其形态，并应用HPLC测定微粒中丹参酮ⅡA的含量。结果：得到桔红色的粉末，在电镜下观察粉末为粒状和片状混合物，聚集成絮状，粒径在2～80μm；混合粒子中丹参酮ⅡA。质量分数为0．54％。结论：该技术可用于中药丹参SCF-CO2萃取物的超微颗粒制备，且操作温度低、工艺流程简单、对环境无污染，无有机溶剂残留。

Objective： Application of rapid expansion of supercritical solution （RESS） in preparing micropaticles of SCF-CO2 extraction of Salvia miltiorrhiza. Method： The mixture which was composed of β-cyclodextrin and SCF-CO2 extraction of S. miltiorrhiza with proportion 8：1 by weight, was granulated by RESS. The characteristics of the resuluhing particles were studied by scanning electron microscopy （SEM） and the assay of salviol ⅡA in particles which was determinated by HPLC. Result： The resulting particles were jacinth and photomicrograph produced by SEM showed that the morphology were silkiness and rugosity globular, the size distribution between 2 and 80 μm, and the contents of salviol ⅡA was 0. 54%. Conclusion： The RESS method is applicable for preparing microparticles of SCF-CO2 extraction of S. miltiorrhiza and low operating temperature, simple processing, and no environmental pollution, and no residual solvent.