牛耳枫与辣蓼提取物药效学研究

Pharmacodynamic Study of Extract of Daphniphullum calucinum Benth and Polygonnm Hydropiper Linn

目的研究牛耳枫与辣蓼提取物的抗急性胃肠炎的作用。方法采用冰醋酸致小鼠毛细血管通透性法、热板法、豚鼠回肠平滑肌运动法和95%乙醇致大鼠胃溃疡法来观察提取物的抗炎、镇痛、解痉和抗胃溃疡作用。结果牛耳枫与辣蓼提取物对醋酸诱导的小鼠腹腔毛细血管通透性增高有显著抑制作用(P<0.01),而无镇痛作用,对BaC l2引起的肠痉挛有明显的解痉作用(P<0.001),对乙酰胆碱引起的肠痉挛无解痉作用,同时具有减小95%乙醇对大鼠胃粘膜损伤的作用。结论牛耳枫与辣蓼提取物具有很好的抗炎、解痉及抗乙醇引起的胃粘膜损伤作用,对胃肠道有很好的保护作用。

OhjectiveTo study the anti - acute gastroenteritis effect of Nuerfeng Lialiao Water extract （NLWE） of mouse. Methods The anti - inflammatory and analgesic effect of NLWE was observed by the permeability of abdominal capillary by injecting glacial acetic acid and hot plate respectively. Effect of NLWE on the contraction of smooth muscles induced by acetylcholine （Ach） or barium chloride （ BaCl2 ） was investigated in ileum in vitro. Protective effect of NLWE was observed on absolute ethanol - induced gastric mucosa damage. Results NLWE had the action of reducing the permeability of abdominal capillary by injecting glacial acetic acid （P 〈 0.01 ）, and had no analgesia effect. NLWE could markedly restrain the contraction of ileum smooth muscles caused by BaCl2 （P 〈 0. 001 ） , but had little influence on that caused by Ach. NLWE could significantly inhibit the formation of acute gastric ulcer induced by absolute ethanol in rats. Conclusion NLWE has significant anti - cnflammatory effect. It can nhibits contraction of smooth muscles and protects stomach of mouse from injury induced by ethanol.