活血通脉片对老年冠心病的疗效观察及机制探讨

Effective Observation and Mechanism of HXTMT on Senile Coronary Heart Disease

目的观察活血通脉片治疗老年冠心病心绞痛的临床疗效,初步探索其作用机制。方法将80例老年冠心病心绞痛患者随机分为活血通脉片组(40例,常规西药加活血通脉片)与单纯西药治疗组(40例,单用西药治疗),观察治疗前后血浆内皮素(ET)与降钙素基因相关肽(CGRP)含量,临床症状和心电图的变化,并选择30例门诊健康体检者为正常组进行对比。结果治疗前与治疗后两组患者ET明显高于健康人(P<0.01),CGRP明显低于健康人(P<0.01),活血通脉组临床疗效总有效率及心电图疗效总有效率明显优于西药对照组(P<0.01);两组患者ET均明显降低,CGRP明显升高,但是活血通脉组优于西药对照组(P<0.01)。结论活血通脉片可抑制血浆ET过量释放,同时提高血浆CGRP浓度,具有良好的抗心肌缺血作用,对老年冠心病心绞痛有较好的疗效。

Objective To observe the curative effect of HXTMT on senile coronary heart disease （CHD） and its mechanism. Methods Eighty patients were divided into two groups randomly. Group Ⅰ （n = 40） was treated by HXTMT adding up general medicine;Group Ⅱ （n = 40）only by common medicine. The changes of the ET and CGRP contents before and after treatment were observed, and the symtpoms and ECG were eompered with healthy people （n = 30）. Results The ET contents of group Ⅰ and Ⅱ were both higher than healthy people before and after treatment （ P 〈 0.01 ）. CGRP was significantly lower than the healthy people, but the group Ⅰ was higher than to the group Ⅱ in general effection and ECG change. Conclusion HXTMT can inhibit the release of serum ET and increase the serum CGRP. There is good effect on ischemis myocardiopathy in CHD.