摘要
微生物间通过群体感应效应进行交流并调控重要基因的转录及表达。目前发现参与这种信息传递最普通的信号分子是N-脂酰高丝氨酸内酯。通过抑制N-脂酰高丝氨酸内酯在群体感应系统中的信号传导,可以阻断病原基因的转录启动,以抑制病原因子的表达和作用,达到抗微生物感染的目的,是一种潜在的防治疾病新途径。
Quorum-sensing response could control the transcription and expression of key genes in microbial cells by concentration of signals autoinducer, in which N-acyl-homoserine-lactones are the gen- eral and global singals. Signal transmission can be quenched by inhibition of N-acyl-homoserineqactone, leading to breaking the initial of pathogenic genes transcription and the expression of virulence. It is a potential application in protection against microbial disease.
出处
《大连工业大学学报》
CAS
2008年第3期197-200,共4页
Journal of Dalian Polytechnic University
基金
国家自然科学基金项目资助(30670067)
