马拉色菌毛囊炎的临床分析及治疗观察

Clinical Analysis and Therapy of Malassezia Folliculitis

目的探讨伊曲康唑与外用复方酮康唑洗剂治疗马拉色菌毛囊炎的临床疗效。方法收集临床症状典型,经真菌学检查确诊的马拉色菌毛囊炎共146例患者的临床资料分为治疗组,餐后口服伊曲康唑200mg,1次/d,连续7d,同时外用2%复方酮康唑洗剂,3次/d,连续用药4周;对照组单纯外用2%复方酮康唑洗剂,3次/d,连续用药4周。结果治疗组4周痊愈率、有效率分别为69.47%和95.79%,明显高于对照组的35.29%和82.35%(P<0.01)。结论口服伊曲康唑与外用2%复方酮康唑洗剂联合治疗安全、有效,值得推广应用。

Objective To investigate the curative effect of itraconazole and the complex lotion of ketoconazole. Methods One hundred and forty six patients with Malassezia folliculitis conformed by fungus examination were collected and divided into two groups. The treatment group treated by itraeonazole（200 mg/d, per oral for 7 days） and complex lotion of ketoeonazole （external application, tid ,4 weeks ）, and the control group only by complex lotion of ketoconazole （external application, rid, 4： weeks ）. Results The cm＇ative ratio and effective rate were 69.47% and 95.79% in the treatment group,35.29% and 82.35% in the control group respectively（P 〈0.01 ）. Conclusions The itraconazole per oral combine with complex lotion of ketoconazole external application is safe and effective for Malassezia follieulitis,and it can be generalized.