胸腺肽辅助治疗梗阻性黄疸的临床意义

Clinical Value of Thymosin in Treatment of Obstructive Jaundice

目的探讨胸腺肽辅助治疗梗阻性黄疸的作用。方法将2005年2月-2007年12月我院收治的48例梗阻性黄疸的患者随机分为用药组(25例)和对照组(23例),在手术减黄治疗的基础上用药组加用胸腺肽,观察2组患者T淋巴细胞亚群及NK细胞百分率的变化以及术后感染的发生率。结果用药组T淋巴细胞亚群及NK细胞百分率较对照组明显升高,用药组术后感染的发生率较对照组明显降低。结论胸腺肽能减轻梗阻性黄疸引起的机体免疫功能抑制,改善机体细胞免疫功能,降低术后感染的发生率。

Objective To investigate the therapeutic function of Thymosin for obstructive jaundice. Methods Forty-eight cases with obstructive jaundice from February 2005 to December 2007 were randomly divided into the treatment group （25 cases） and control group（23 cases）. Thymosin was used in the treatment group on the basis of operative biliary drainage. The percent of CD3, CD4, CD8, NK cell and the incidence of postoperative infection were observed. Results The percent of CD3, CD4, NK cell increased more significantly in Thymosin treatment group compared to the control group, and the incidence of postoperative infection in the treatment group was lower than that in the control group. Conclusions Thymosin can mitigate the immunosuppression caused by obstructive jaundice, improve the cellular immunity function of the host, decrease the incidence of postoperative infection.