摘要
目的为减少恶性肿瘤病人术中输血甚至术中不输血,同时能够迅速纠正恶性肿瘤病人低血容量的病理状态,使重要脏器得到有效灌注,应用高渗氯化钠羟乙基淀粉40注射液（霍姆）快速输入,通过监测血压、心率、尿量的变化,评价该溶液在恶性肿瘤病人根治性手术中维持有效血容量的效果。方法选择临床明确诊断为恶性肿瘤并需行根治性手术的患者60例,应用高渗氯化钠羟乙基淀粉40注射液经静脉输入,速度10~15ml/min,测定并记录用药前及用药后血压、心率、尿量的变化。为排除剂量对试验结果的影响,高渗氯化钠羟乙基淀粉40注射液输入量统一为250ml。继以林格氏液维持输液,记录实际输入量。结果用药后血压、尿量较用药前明显增高,心率过快者心率减慢。在恶性肿瘤病人根治性手术中维持有效血容量的效果为100%。平均用药时间（21±4）min。结论高渗氯化钠羟乙基淀粉40注射液能够安全的应用于肿瘤根治性手术的病人,血流动力学维持稳定,可有效的提高机体对失血的耐受性,明显减少异体输血量。
Objective To valuate the curative effect of hyperosmotic sodium chloride hetastarch 40 injection on sustaining effective blood volume to patients of malignant neoplastic disease received surgery. Methods Sixty patients diagnosised malignant neoplastic disease and received radical surgery were selcted. They were infused hyperosmotic so- dium chloride hetastareh 40 injection by intravenous ways and then recorded changes of blood pressure, heart rate, uri- nary volume before and after using this kind of solution. To remove effect of dosage on experiment result, the dosage is unifed as 250 ml. Results Blood pressure and urinary volume increased after using this kind of solution, however the heart rate slowed down. It can get satisfied effect on sustaining effective blood volume and just takes（21±4）minute. Conclusions Hyperosmotic sodium chloride hetastarch 40 injection can be used safely on patients of neoplastic disease who got radical surgery. It can improve tolration of patients to bloodlss, decrease the volume of variant blood transfusion.
出处
《医学信息（手术学分册）》
2008年第8期675-676,678,共3页
Medical Information Operations Sciences Fascicule
