C-反应蛋白在小儿支原体肺炎中的检测价值

Diagnostic Value of C-reactive Protein in Infant with Mycoplasma Pneumonia

研究C反应蛋白(CRP)在小儿支原体肺炎中的应用价值。采用胶乳强化浊度法测定128例支原体肺炎和79例细菌性肺炎患儿血清CRP,与51名健康儿童作对比。结果表明,128例支原体肺炎组(A组)CRP阳性者45例,阳性率为35.2%,其中3例重症支原体肺炎患儿CRP大于80mg/L。79例细菌性肺炎组(B组)CRP阳性者为73例,阳性率为92.4%,对照组51名(C组)CRP阳性者为2例,阳性率为3.9%。A组、B组与C组相比较有显著性差异(P<0.01),A组与B组相比也有显著性差异(P<0.01)。对于一般非重症肺炎,支原体肺炎患儿CRP稍高,但没有细菌性肺炎增高明显,CRP可作为鉴别支原体肺炎或细菌性肺炎的重要辅助指标。

To explore the diagnostic value of C-reactive protein（CRP） in infant with mycoplasma pneumonia, the serum CRP levels were measured by nephelometric immunoassay and ELISA in 258 infants with pneumonia and 51 healthy children. The results showed that there were 45 cases with positive serum CRP in 128 infants with mycoplasma pneumonia （group A）. The serum CRP level was more than 80 mg/L in 3 cases with serious mycoplasma pneumonia. There were 73 cases with positive serum CRP in 79 infants with bacteria pneumonia（group B）. There were 2 cases with positive serum CRP in 51 healthy children. The positive rate of serum CRP in group A and group B was significantly higher than that of healthy controls （P〈0.01）. The incidence of positive serum CRP in group A was significantly higher than that in group B （ 0.01）. The results indicate that the serum CRP level could be an important index in the differential diagnosis of bateria or mycoplasma pneumonia.