射频消融术对血栓前状态的影响及其拉西地平防治的观察

Effect of radiofrequency ablation on Prethrombotic state and prophylactic therapy of Lacidipine

目的探讨射频消融术(RFCA)对血栓前状态的影响及其拉西地平的防治效果。方法采用双抗体夹心酶联免疫吸附法(ELISA)、发色底物法和Born比浊法,观察60例患者RFCA术前、术后血浆中血管性血友病因子(vWF)、可溶性P-选择素(sP-selection)、D-二聚体(DD)、纤溶酶原激活物抑制物-1(PAI-1)和血小板聚集率(PAG)的变化,并观察拉西地平的干预效果。结果对照组vWF、sP-selection、D-Dimer、PAI-1和PAG在RFCA术后明显升高,其差异有统计学意义(P<0.05);采用拉西地平的患者术后以上指标较术前也有所增高,但差异无统计学意义(P>0.05)。结论射频消融术可促进血栓前状态的形成,拉西地平有预防作用。

Objectives To investigate the influence of radiofrequency catheter ablation（RFCA） on Prethrombotic State （PTS） and evaluate the effect of prophylactic therapy of Lacidipine. Methods With enzyme linked immunosorbent assay,chromogenic substances assay and furbidimetry assay, sixty consecutive patients were divided randomly into two groups：the control group （30 cases）treated with no drug and the treated group（30 cases）treated with Lacidipine. The levels of Von Willebrand＇s factor（ vWF）, soluble P-selection,D-Dimer,plasminogen activator inhibitor（ PAI-1 ）and maximum platelet aggregation rate（ PAG- max）were measured before and immediately after RFCA. Results In control group,the plasma levels of vWF,sP-selection,D-Dimer,PAI -1 and PAGmax were increased significantly immediately after RFCA as compared with those before RFCA. In treated group,the levels of those markers were also increased slightly, but there were no statistical significance. Conclusions It suggests that PTS may be introduced by RFCA, and prophylactic therapy of lacidipine may prevent it. Mornitoring the plasma levels of those markers of PTS is valuable in guiding the administration of anticoagulative drugs and prophylaxis of thromboembolic disease.