银杏叶提取物对血脑屏障通透性保护作用的分子机制

Effects of Ginkgo biloba extract on the permeability of the blood-brain barrier and the molecular mechanisms

阐述了病理条件下,血脑屏障通透性改变过程中几种重要蛋白分子改变对血脑屏障通透性的影响及相关机制。同时,根据临床应用中的特点,从调节紧密连接蛋白、基质金属蛋白酶(MMPs)、水通道蛋白4(AQP4)的表达,减少氧自由基生成和促进氧自由基清除,阻断凝血因子的激活和减少炎症介质生成等5个方面介绍了中药银杏叶提取物对血脑屏障通透性的保护作用及分子机制,为银杏叶制剂应用于临床血脑屏障通透性改变所致疾病的治疗及相关药物的开发提供了理论依据。

This article reviewed the changes in several important proteins and their effect on the alteration of blood-brain barrier （BBB） permeability under the pathological conditions. In addition, we also discussed the protective effects of Ginkgo biloba extract （GBE） on the permeability stability of BBB and the molecular mechanism in 5 aspects： tight junction proteins; matrix metalloproteinases; aquaporin-4; decrease or elimination of oxygen radicals; blood clotting blocking and decrease in inflammatory mediators. This review would provide theoretical basis for the treatment of the BBB permeability-related diseases, as well as the application and development of GBE related medicines.