葡萄籽原花青素提取物的研究进展

Advances in research of grape seed proanthocyanidin extracts

葡萄籽原花青素提取物是具有多种重要生物活性和药理作用的天然植物药,有着极强的抗氧化及清除自由基活性,能通过保护血管内皮功能、抗心肌氧化应激损伤及抑制低密度脂蛋白的氧化等多种机制抗心血管疾病,另外包括抗DNA氧化损伤和脂质过氧化、抗肿瘤、抗炎、抗伤害和镇痛以及预防牙周病、糖尿病和白内障等多种药理作用,对人类健康有着多方面的益处,成为近年研究的热点。文中对近几年葡萄籽原花青素提取物在药理作用和应用方面的研究进展做一综述。

Grape seed proanthocyanidin extracts （GSPE） consist of many polyphenols or phenolic compounds with multiple important biological activities. GSPE possess potent antioxidant ability, free radical scavenging properties and a wide variety of pharmacologic actions, including cardioprotection, reducing oxidized LDL, inhibiting oxidative damage of DNA and lipid peroxidation, anti-carcinogenic and anti-inflammatory activities, antino-ciceptive effect, as well as preventive effects on periodontal disease, diabetes, and cataract. It is beneficial for human health, and has become one of the hot spots currently. This article summarized new researches on its pharma-cologic actions and applications.