Ki-67在喉鳞状细胞癌的表达及临床病理学意义

The Expression of Ki-67 in Laryngeal Squamous Carcinoma and Its Clinical Pathological Significance

目的:探讨Ki-67在喉鳞状细胞癌的表达及临床病理学意义。方法:采用免疫组化技术检测10例声带息肉、20例不典型增生病变和50例喉鳞癌组织中Ki-67的表达。结果:Ki-67阳性表达定位于细胞核,Ki-67在声带息肉组、不典型增生组和喉鳞癌组的阳性表达率分别为10%、25%和78%,统计学上有显著性差异,且Ki-67LI同肿瘤位置、组织学分级、临床分期及淋巴结是否转移相关。结论:Ki-67抗原在喉癌中具有显著的临床病理学意义,能用来反映喉癌的良恶性程度。

Objeetive： To investigate the expression of Ki- 67 in laryngeal squamous careinoma（LSCCs）arid its clinical pathological significance. Methods： The expression of Ki - 67 in 10 cases of polyp of vocal cord, 20 cases of atypical hyperplasia and 50 cases of LSCCs was detected by immunohistochemistry methods. Results. The positive expression of Ki - 67 was localized in the nuclei. The rate of positive expression of Ki - 67 in polyp of vocal cord, atypical hyperplasia and LSCC was respectively 10 %, 25 % and 78 %, the difference was statistically different. The expression of Ki - 67 was related to locations of tumors, grading, clinical staging and lymphatic metastasis. Conclusion： The expression of Ki- 67 may indicate the pathological grading of LSCCs.