摘要
蛋白酶激活受体-2（PAR-2）属于与G蛋白相耦联的受体家族，其N-末端被蛋白酶裂解后形成新的N-末端。新N-末端能够结合、激活受体自身。最新资料表明，PAR-2可表达于某些肿瘤组织及培养细胞，与肿瘤细胞的增生、侵袭与转移及血管生成等密切相关。
Protease-activated receptor-2 （PAR-2） belongs to the receptor family which is coupled with G-protein. The N-terminus of PAR-2 is cleaved by some proteases to generate a new N-terminus. The new N-terminus can interact with and activate the receptor itself. The update research reported that PAR-2 could be expressed on some cancers as well as tumor cell lines. There are some relationships between the PAR-2 expression and the behaviors of tumor cell, such as proliferation, angiogenesis, migration and invasion.
出处
《肿瘤研究与临床》
CAS
2008年第9期646-648,共3页
Cancer Research and Clinic
基金
教育部回国人员科研启动基金（教外司[2003]406）
