热休克蛋白HSPgp96在骨肉瘤中的表达及意义

Expression and significance of HSPgp96 in osteosarcoma

目的观察热休克蛋白(HSP)gp96在骨肉瘤中的表达及其临床意义。方法30例骨肉瘤患者为观察对象(骨肉瘤组),10例骨软骨瘤患者切除肿瘤后的基底部周围正常骨组织为对照组。用SP法免疫组织化学标记HSPgp96及C-erbB2基因。结果各组织学类型的骨肉瘤细胞均有HSPgp96阳性表达。骨肉瘤组HSPgp96及C-erbB2的表达均明显高于对照组(P<0·05)。分化较差的骨肉瘤HSPgp96的表达强度明显高于分化较好者(P<0·01)。结论HSPgp96在骨肉瘤的增殖过程中发挥重要作用。

Objective To study the expression and clinical significance of heat shock protein （HSP）gp96 in osteosarcorna. Methods The expressions of HSPgp96 and C-erbB2 were detected by SP immunohistochemical technique in 30 patients with osteosarcoma and normal bone tissues of 10 cases with osteochondroma as the controls. Results The HSPgp96 expressed in each of osteosarcoma types. Positive expressions of HSPgp96 and C-erbB2 were higher in osteosarcoma patients than those in the controls （P〈0. 05）. The positive expression of HSPgp96 in low grade osteosarcomas was higher than that in high grade （P〈 0.01）. Conclusion HSPgp96 plays an important role in the development and progression of osteosarcoma.