ESM-1、VEGF在非小细胞肺癌中的表达及意义

Expression and significance of endocan and VEGF in non small cell lung cancer

目的研究内皮细胞特异分子-1(endocan,ESM-1)、血管内皮细胞生长因子(VEGF)在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法应用免疫荧光技术检测60例NSCLC组织、21例癌旁肺组织中的ESM-1表达水平,免疫组化(SP法)检测VEGF,并计数微血管密度(MVD)。结果在NSCLC组织中,ESM-1和VEGF均呈高表达;ESM-1、VEGF的表达与NSCLC的淋巴结转移、TNM分期呈正相关,而与NSCLC的组织学分类无关;ESM-1、VEGF的表达与NSCLC中的MVD呈正相关。结论ESM-1、VEGF与NSCLC的血管生成有密切的关系,同时两者有可能是NSCLC进展和预后不良的生物学标记。

Objective To investigate the expression and clinical significance of endocan and vascular endothelial growth factor （VEGF） in non-small cell lung cancer（NSCLC）. Methods The expression of endocan was detected using immunofluorescence technique in 60 specimens of NSCLC and 21 specimens of cancer-adjacent tissues. Immunohistochemical SP method was used to estimate the expression of VEGF and microvessel density（MVD）. Results The expressions of endocan and VEGF in NSCLC tissues were higher than those in the cancer-adjacent tissues. The expressions of endocan and VEGF were associated with lymph node metastasis and TNM stage, but not associated with the histological type of NSCLC. There was a positive correlation among the expressions of endocan and VEGF in NSCLC. The expressions of endocan and VEGF in NSCLC tissues were positively correlated with MVD. Conclusion Endocan and VEGF might play very important roles in tumor angiogenesis in NSCLC. Endocan and VEGF might be the biological markers for advanced stage of lung cancer and poor prognosis.