人尿液中异黄酮水平与子宫内膜癌的关系

The relationship between urinary isoflavone levels and the risk of endometrial cancer

目的:探讨人尿液中异黄酮水平与子宫内膜癌的关系。方法:采用病例对照研究的方法,应用高效液相色谱法对200例子宫内膜癌病例和200例对照者尿液中4种异黄酮组分进行检测。采用非条件logistic回归模型计算分析尿液中4种异黄酮组分与子宫内膜癌的关系。结果:与对照组相比,病例组尿液中染料木黄酮(genistein)的水平较高,病例组和对照组尿液中genistein水平的中位数(第25%百分位数,第75%百分位数)分别为4.72(1.19,10.79)nmol/mgCr和2.43(0.90,9.16)nmol/mgCr,P<0.05。其他3种大豆异黄酮组分在尿液中的水平没有显著差异。调整了年龄、初潮年龄、行经年数、是否服用口服避孕药、体质指数、腰臀比等混杂因素后,未发现尿液中异黄酮水平与子宫内膜癌的危险性有关。结论:人尿液中4种异黄酮组分的水平与子宫内膜癌之间没有关联。

Objective：To investigate the relationship between urinary excretion of isoflavones and the risk of endometrial cancer. Methods： Case-control study was used. Overnight urine samples were collected from 200 endometrial cancer cases and 200 controls. HPLC analysis was applied to quantify the urinary levels of daidzein, genistein, glycitein and equol. Non-conditional logistic regression was used to analyze the association of urinary level of the four isoflavones with the risk of endometrial cancer. Results：The urinary genistein level was substantially higher in endometrial cancer cases compared with controls. The median （25% , 75% ） levels was 4.72 （ 1.19, 10.79） nmol/mg Cr for endometrial cancer patients and 2.43 （0.90, 9.16） nmol/mg Cr for controls （ P 〈 0.05 ）. There was no significant difference in the urinary levels of other three isoflavones. No relationship was found between urinary isoflavones levels and the risk of endometrial cancer after adjusted for possible confounding factors such as age, menarcheal age, menstrual years, administra- tion of oral contraceptive pills, BMI, and waist to hip ratio. Conclusion： No significant difference is found between urinary levels of isoflavones and risk of endometrial cancer.