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腺相关病毒Rep78/68蛋白

Rep78/68 protein of adeno-associated virus
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摘要 腺相关病毒(AAV)编码的非结构蛋白Rep78/68具有抑制病毒和肿瘤转化的作用,并且对宿主细胞的增殖及代谢产生广泛地影响。本文将对此蛋白的最新研究进展进行综述。 Rep78/68 is a kind of nonstructural protein from adeno-associated virus. It inhibits a variety of viruses and tumor transformation. In addition, it has significant effect on the proliferation and metabolism of host cells. In this paper, we reviewed the latest research advances of this protein.
作者 刘天会 尤红
机构地区 首都医科大学附属北京友谊医院肝病中心
出处 《基础医学与临床》 CSCD 北大核心 2008年第9期998-1000,共3页 Basic and Clinical Medicine
基金 国家自然科学基金(30500425) 霍英东教育基金(101039)
关键词 Rep78/68蛋白 腺相关病毒 肿瘤转化 Rep78/68 protein adeno-associated virus tumor transformation
分类号 R373 [医药卫生—病原生物学]
  • 相关文献

参考文献12

  • 1Needham PG, Casper JM, Kalman-Maltese V, et al. Adeno-associated virus rep protein-mediated inhibition of transcription of the adenovirus major late promoter in vitro [ J ]. J Virol, 2006, 80(13) :6207 -6217.
  • 2刘天会,丛敏,王萍,唐淑珍,王宝恩,贾继东,尤红.腺相关病毒主要调控蛋白Rep78的表达及其与HBV-X基因启动子的体外结合[J].首都医科大学学报,2006,27(4):423-426. 被引量：2
  • 3刘天会,丛敏,王萍,唐淑珍,刘晓明,王宝恩,贾继东,尤红.腺相关病毒Rep78蛋白抑制乙型肝炎病毒复制的体外研究[J].肝脏,2006,11(6):396-398. 被引量：3
  • 4阎钟钰,丛敏,王萍,唐淑珍,王宝恩,贾继东,刘勇,尤红.腺相关病毒Rep78蛋白对乙型肝炎病毒C基因的抑制作用[J].中华肝脏病杂志,2005,13(3):187-189. 被引量：3
  • 5Batchu RB, Shammas MA, Wang JY, et al. Dual Level Inhibition of E2F-1 Activity by adeno-associated Virus Rep78 [J]. JBC, 2001,276(26) :24315 -24322.
  • 6Schmidt M, Afione S, Kotin RM. Adeno-Associated Virus Type 2 Rep78 Induces Apoptosis through Caspase Activation Independently of p53[J]. J Virol, 2000,74(20) :9441 - 9450.
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  • 9Weger S, Hammer E, Heilbronn R. SUMO-I modification regulates the protein stability of the large regulatory protein Rep78 of adeno associated virus type 2 (AAV-2) [J]. Virology, 2004,330( 1 ) :284 - 294.
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二级参考文献18

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  • 3Batchu RB, Miles DA, Rechtin TM, et al. Cloning, expression and purification of full length Rep78 of adeno-associated virus as a fusion protein with maltose binding protein in Escherichia coli. Biochem Biophys Res Commun, 1995, 208: 714-720.
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基础医学与临床
2008年 第9期

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