骨形成因子及其信号传导通路述评

Factors affecting bone formation and corresponding singnal transduction

骨生成和骨重建是成骨细胞和破骨细胞共同作用的结果。一方面,成骨细胞在骨形成中受多因素影响,特别是骨形态发生蛋白(BMP),它能诱导间充质细胞向软骨转化,并能在细胞和细胞间质之间进行信号传导,包括Smads路径、MAPKs路径。另一方面,破骨细胞的骨吸收作用主要受OPG、RANKL、1,25-(OH)2D3等作用,其信号传导通路主要有p38MAPK、CN/NFAT、PI3K/Akt等。通过以上两方面综述,为骨生成和骨重建提供有效的理论基础,从而为骨质疏松或运动后骨创伤的治疗和预防提供参考。

Bone build and rebuild are the result of cooperation of osteoblasts cells and osteoelast cells. On the one hand, osteoblast cells is affected by multi-factors during bone formation, especially the effect of bone morphogenetic protein （BMP） which can induce mesenchymal cells into cartilage, and transduct signal between the stromal cells and mesenchymal cells, including Smads path, MAPKs path. On the other hand, the osteoclast bone resorption is affected mainly by OPG, RANKL, 1,25-（OH）2D3 and so on. The signal transduction pathways in osteoclast include p38MAPK, CN/NFAT, PI3K/Akt, etc. After reviewing above two aspects, we can now provide effective theoretical basis about bone reconstruction, so as to provide an effective way for osteoporosis, bone trauma or fracture after exercise.