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糖尿病合并Graves眼病者需慎用过氧化物酶体增殖物激活受体γ激动剂 被引量:1

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摘要 过氧化物酶体增殖物激活受体(PPAR)γ激动剂噻唑烷二酮类药物的应用是近年2型糖尿病治疗的主要进展之一。但自2003年以来,陆续有报道在合并Graves眼病(GO)的糖尿病患者中应用噻唑烷二酮类药物后,GO有恶化倾向^[1-4],因而有关PPARγ与GO发病的关系越来越引起人们的重视。
作者 王坚 叶小珍
出处 《内科理论与实践》 2008年第5期332-334,共3页 Journal of Internal Medicine Concepts & Practice
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参考文献2

  • 1Yasuhiro Nishida,Suna Tian,Bengt Isberg,Osamu Hayashi,Leif Tallstedt,Gunnar Lennerstrand. Significance of orbital fatty tissue for exophthalmos in thyroid-associated ophthalmopathy[J] 2002,Graefe’s Archive for Clinical and Experimental Ophthalmology(7):515~520
  • 2A.K. Hihi,L. Michalik,W. Wahli. PPARs: transcriptional effectors of fatty acids and their derivatives[J] 2002,Cellular and Molecular Life Sciences(5):790~798

同被引文献23

  • 1廖光新.Graves眼病治疗现状与前景[J].中国医学文摘(内科学),2005,26(5):667-669. 被引量:1
  • 2傅德生,许雪亮.IFN-γ对球后成纤维细胞增殖的影响[J].国际眼科杂志,2006,6(3):615-617. 被引量:3
  • 3傅德生,许雪亮.重组人干扰素γ对球后成纤维细胞CD40 mRNA表达的影响[J].福建医科大学学报,2007,41(1):25-28. 被引量:2
  • 4段春青,孙斌.ICAM-1、VCAM-1在甲状腺相关性眼病发病机制中的研究新进展[J].山西医科大学学报,2007,38(9):858-862. 被引量:1
  • 5van Steensel L, Dik WA. The orbital fibroblast: a key player and target for therapy in Graves' ophthalmopathy [J]. Orbit, 2010, 29(4): 202-206.
  • 6Lahooti H, Parmar KR, Wall JR. Pathogenesis of thyroid- associated ophthalmopathy: does autoimmunity against calsequestrin and collagen ⅩⅢ play a role?[J]. Clin Ophthalmol, 2010, 4: 417-425.
  • 7Garrity JA, Bahn RS. Pathogenesis of Graves ophthal- mopathy: implications for prediction, prevention, and treatment[J]. Am J Ophthalmol, 2006, 142(1): 147-153.
  • 8Agretti P, De Marco G, De Servi M, et al. Evidence for protein and mRNA TSHr expression in fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) after adipoeytic differentiation[J]. Eur J Endocrinol, 2005, 152(5): 777-784.
  • 9Pritchard J, Han R, Horst N, et al. Immunoglobulin acti- vation of T cell chemoattractant expression in fibroblasts from patients with Graves' disease is mediated through the insulin-like growth factor Ⅰ receptor pathway [J]. J Immunol, 2003, 170(12): 6348-6354.
  • 10Gianoukakis AG, Khadavi N, Smith TJ. Cytokines, Graves' disease, and thyroid-associated ophthalmopathy [J]. Thyroid, 2008, 18(9): 953-958.

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