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线粒体是防治心力衰竭的重要靶点 被引量:12

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摘要 慢性心力衰竭(心衰)是一种因心脏充盈和射血功能衰减而使循环血量不能满足全身代谢需求的病理生理综合征,是各种器质性心脏病的终末阶段。由于各种病理因素刺激引起左心室壁重构,导致缓慢的心脏收缩舒张功能紊乱。心衰的急性发作归因于心脏的失代偿,因一些急性并发症(如心肌梗死、心律失常、脓血症)而引起。在心衰患者中,20%-30%为中等程度的心衰,严重心衰〉50%。
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2008年第9期854-858,共5页 Chinese Journal of Cardiology
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