心脏再同步化治疗时跨壁复极离散度的促心律失常作用及其预防
摘要
以双心室同步为核心的心脏再同步化治疗(cardiac resynchronization therapy,CRT)能有效改善慢性心力衰竭(心衰)患者心功能和生活质量,但双心室同步起搏实际是右心室内膜和左心室外膜的同步起搏,这种非生理的心室激动顺序增加了室性心律失常的风险。本文综述了CRT术后心衰患者跨壁复极离散度的变化和室性心律失常的内在机制,并初步探讨了有关防治措施。
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2008年第9期859-861,共3页
Chinese Journal of Cardiology
参考文献20
-
1Gaita F, Bocchiardo M, Porciani MC, et aL Should stimulation therapy for congestive heart failure be combined with defibrillation backup. Am J Cardiol, 2000,86 : 165-168.
-
2Bradley DJ, Bradley EA, Banghman KL, et al. Cardiac resynchronization and death from progressive heart failure: a meta- analysis of randomized controlled trials. JAMA, 2003,289 : 730- 740.
-
3Shukla G, Chaudhry GM, Orlov M, et aL Potential proarrhythmic effect of biventricular pacing: fact or myth7 Heart Rhythm,2005, 2:951-956.
-
4Medina-Ravell VA, Lankipalli RS, Yan GX, et al. Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization. Does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes. Circulation ,2003,107:740-746.
-
5Oikarinen L, Nieminen MS, Viitasalo M, et al. Relation of QT interval and QT dispersion to echocardiographic left ventricular hypertrophy and geometric pattern in hypertensive patients-The LIFE study: The Losartan Intervention For Endpoint Reduction. J Hypertens, 2001, 19 : 1883-1891.
-
6Gordon IT, Eduardo M. Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res, 1999, 42: 270- 283.
-
7Tomaselli GF, Marban E. Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res, 1999,42: 270- 283.
-
8Marban E. Heart failure: the electrophysiologic connection J Cardiovasc Electrophysiol, 1999,10 : 1425-1428.
-
9Asano Y, Davidenko JM, Baxter WT, et aL Optical mapp ing of drug-induced polymorphic arrhythmias and torsade de pointes in the isolated rabbit heart. J Am Coll Cardiol, 1997, 29: 831-842.
-
10Shimizu W, Antzelevitch C. Effects of a K ^+channel opener to reduce transmural dispersion of depolarization and p revent torsade depointes in LQT1, LQT2 and LQ33 models of the long QT syndrome. Circulation, 2000, 102 : 706-712.
二级参考文献20
-
1刘念,喻荣辉,阮燕菲,周强,卜军,李泱.卡维地洛对氧自由基所致心肌细胞L型钙电流异常的保护作用[J].中华心血管病杂志,2004,32(6):538-541. 被引量:14
-
2王军奎,崔长琮,张虹,姚青海,姚晓伟,陈新义.肾上腺素能受体阻断剂预防慢性压力超负荷左心室的电重构(英文)[J].生理学报,2004,56(4):487-492. 被引量:7
-
3姚青海,崔长琮,王军奎,姚晓伟,陈少伯.伊文思兰对兔左室心肌灌注范围显示效果及跨膜动作电位的影响[J].四川大学学报(医学版),2004,35(5):719-722. 被引量:1
-
4姚青海,崔长琮,姚晓伟,王军奎,廉姜芳,韩克.慢性压力超负荷对兔左心室结构及功能的影响[J].西安交通大学学报(医学版),2004,25(6):545-548. 被引量:3
-
5姚青海,崔长琮,吴尚勤,孙姗,董其克,陈冬梅.兔肥厚左心室跨壁复极离散度和室性心律失常发生机制[J].中华心律失常学杂志,2006,10(2):153-157. 被引量:7
-
6Oikarinen L,Nieminen MS,Viitasalo M,et al.Relation of QT interval and QT dispersion to echocardiographic left ventricular hypertrophy and geometric pattern in hypertensive patients-The LIFE study:The Losartan Intervention For Endpoint Reduction.J Hypertens,2001,19:1883-1891.
-
7Gordon FT,Eduardo M.Electrophysiological remodeling in hypertrophy and heart failure.Cardiovasc Res,1999,42:270-283.
-
8Casico WE.Myocardial ischemia:What determine arrrhythmogenesis?J Cardiovasc Electrophysiol,2001,12:726-729.
-
9Sweeney MO.Sudden death in heart failure associated with left ventricular function:substrates,mechanism,and evidence-based management,part 1.PACE,2001,24:871-887.
-
10Yan GX,Ying Wu,Liu TX,et al.Phase 2 early After-depolarization as a Trigger of Polymorphic Ventricular tachycardia in acquired Long-QT syndrome.Circulation,2001,103:2851-2856.
共引文献6
-
1姚青海,崔长琮,王东琦,马奕,吴尚勤,孙姗,董其克.卡维地洛对慢性压力超负荷兔左心室跨壁复极离散度的影响[J].中华心律失常学杂志,2007,11(5):378-382. 被引量:1
-
2姚青海,王东琦,崔长琮,马奕,吴尚勤,孙珊,董其克.急性心肌缺血时肥厚左心室跨壁复极离散度及心律失常发生机制[J].临床心血管病杂志,2008,24(5):385-388. 被引量:8
-
3肖业伟,何光凤,杭永伦,刘希秀,冯志强,盘强文.同步记录无损伤心内、外膜心肌MAP对比研究[J].中国现代医生,2008,46(31):49-50. 被引量:2
-
4侯丽芳,肖业伟,冯志强,盘强文.无创肢体缺血预处理对兔缺血心肌电稳定性的影响及机制研究[J].泸州医学院学报,2009,32(5):465-468. 被引量:3
-
5肖业伟,何光凤,刘紫全,刘希秀,冯志强,盘强文.丹参注射液对兔室性心律失常心外膜单相动作电位的影响[J].时珍国医国药,2009,20(10):2512-2513. 被引量:6
-
6汤建武,王丹,童元焱.慢性心力衰竭与QT离散度关系的探讨[J].当代医学,2010,16(12):85-85. 被引量:6
-
1叶金朝.抗心律失常药物的促心律失常作用[J].临床荟萃,1997,12(5):228-230.
-
2罗建良.美托洛尔治疗室性期前收缩的疗效观察[J].中外医疗,2008,27(19). 被引量:1
-
3刘燕平,王娟,安爱麒.胺碘酮治疗室性心律失常伴心衰的疗效观察[J].包头医学院学报,2004,20(4):324-325. 被引量:2
-
4王福军,慈书平,张亚斋.抗心律失常药物的促心律失常作用[J].当代医师,1998,3(2):50-51. 被引量:5
-
5谭朝阳,张司兰.稳心颗粒联合倍他乐克治疗心房颤动40例临床分析[J].实用中医药杂志,2011,27(5):360-360. 被引量:7
-
6潘有平.盐酸胺碘酮治疗中老年人室性心律失常66例疗效分析[J].右江医学,2011,39(2):200-201.
-
7梁义秀,宿燕岗.再同步化治疗的致室性心律失常作用[J].中国心脏起搏与心电生理杂志,2009,23(4):303-305. 被引量:17
-
8彭建强,唐奇云.抗心律失常药物的促心律失常作用(附36例分析)[J].实用心脑肺血管病杂志,1996,4(1):14-15.
-
9郑勇,蔡洪斌.腺苷对阵发性室上性心动过速的疗效和促心律失常作用[J].福建医科大学学报,2003,37(3):333-335. 被引量:2
-
10宋仪利,庄鹏.抗心律失常药物促心律失常作用若干认识[J].医学理论与实践,2000,13(5):318-319.