101例新生儿唇腭裂临床统计与病因分析

Clincal features and etiology analysis of 101 patients with cleft lip and palate

1961年1月1日～1995年12月30日,在武汉市第二医院住院分娩97685例活产新生儿中共检出唇腭裂101例,唇腭裂发生率为1.03‰,其中,唇裂占37.62％,腭裂18.81％,唇裂伴腭裂43.57％。统计学分析发现在不同胎次和不同新生儿体重组别中,唇腭裂的发生率有显著性差异(P<0.01)。推测唇腭裂畸形的发生与母体分娩过多,生殖机能减退,生殖器官衰老及胎儿的营养状况有一定关系。

101 Patients with cleft lip and palate was detected in 97685 live newborn babies. Incidence of cleft lip and palate was 1.03‰, Cleft lip was 37.62 % in total 101 patients, cleft palate was 18.81%, cleft lip combined cleft palate was 43. 57% .The incidence of cleft lip and palate in different number of pregnancy and different weight of newborn baby had significant difference. The result suggests that occurrence of cleft lip and palate is related to genital function of parent substance and nutriture of fetus.