AgNOR变化对地方性甲状腺肿的诊断学意义

THE DIAGNOSTIC SIGNIFICANCE OF AgNOR ALTERATION FOR ENDEMIC GOITER

对70例地方性甲状腺肿病变细胞核内AgNOR进行研究。结果表明,乳头状增生结节滤泡上皮细胞核内AgNOR颗粒均数分别与胚胎型、胎儿型、胶质潴留型结节和滤泡型结节的均数比较,均存在显著性差异(P<0.01)。因此,作者认为AgNOR染色方法对地方性甲状腺肿各结节类型的区别和预后判断有重要意义。

Nucleolar organizer region associated protein (AgNOR ) was used to investigate the changes of nulcear AgNOR with the resected endemic goiter specimens of 70 cases. The results showed that there was significant difference in the mean number of the AgNOR between papillary nodules with embryonal nodule and fetal nodule and follicular nodule and colliod retention nodule respectively(P<0. 01). These results suggest that this method may play roles in differentiating histological type and prognostic determination of endemic goiter.