慢性乙型肝炎患者外周血中睾酮的变化及其意义

Changes of Testosterone in the Peripheral Blood of Patients with Chronic Hepatitis B and its Significance

测定65例慢性乙型肝炎患者和35例健康者血清睾酮水平,并分别检测血清丙氨酸氨基转移酶(alanine aminotransferase,ALT)、谷氨酸氨基转移酶(aspartate aminotransferase,AST)、γ-谷氨酰基转肽酶(gamma-glutamyl transpeptidase,GGT)、血清总胆红素(total bilirubin,TBIL)、碱性磷酸酶(alkaline phosphatase,ALP)、免疫球蛋白IgG、IgM、IgA,荧光定量PCR检测外周血HBV DNA水平。慢性乙型肝炎患者血清睾酮水平显著高于正常对照组,HBeAg阳性患者较HBeAg阴性患者升高明显,但差别无显著意义。慢性乙型肝炎患者肝功血清学指标ALT、AST、TBIL、GGT、ALP及IgG水平显著高于正常人,但乙肝患者睾酮水平与ALT等生化指标及HBV DNA水平无明显相关性,与免疫球蛋白IgG呈中等负相关。因而可以看出慢性乙型肝炎患者血清睾酮水平显著高于正常人,睾酮水平升高可作为慢性乙型肝炎的易感因素之一。

Testosterone concentrations in serum were detected in 65 chronic hepatitis B subjects and 35 healthy controls. Meanwhile, alanine aminotransferase（ ALT）, aspartate aminotransferase（ AST）, gamma- glutamyltranspeptidase （ GGT ） , Serumtotal bilirubin（TBIL） ,alkaline phosphatase（ALP） and IgG, IgM or IgA were analyzed. HBV DNA level was analyzed using real-time PCR. Serum testosterone concentration in chronic hepatitis B group was higher than that of healthy controls significantly. Though the testosterone in HBeAg positive subjects was higher than that of HBeAg negative group, there was no significant difference. In addition, ALT, AST, TBIL, GGT, ALP and IgG level were higher than those of controis. In chronic hepatitis B group, serum testosterone was not correlated with ALT, AST, TBIL, GGT, ALP and HBV DNA level. While testosterone was negatively correlated with IgG moderately. Serum testosterone in chronic hepatitis B subjects is significant higher than healthy controls. Therefore, higher testosterone could be as one kind of susceptible factors of chronic hepatitis B.