摘要
Bcl-xL是Bcl-2家族的重要成员,在抑制细胞凋亡中发挥了重要作用.凋亡是由基因调控的细胞主动自杀过程,机体通过凋亡将衰老畸变的细胞从体内清除掉以维持内环境的稳定.Bcl-xL抑制凋亡的作用在肿瘤的发生、发展及耐药性中发挥了重要作用.本文就Bcl-xL的结构表达、调控、功能、与肿瘤关系以及在耐药性中所起的作用作一综述.
Apoptosis is a physiological process that an organism selectively eliminates cells that are no longer needed, or have been damaged, or are dangerous. Bcl-xL, an important member of the Bcl-2 family that plays indispensable roles in regulating cell survival and apoptosis, is frequently over-expressed in various kinds of human cancers. The inhibition of this molecule is associated with decreased tumorigenesis and resistance to conventional chemotherapy. This article briefly reviews some progresses in the study of Bcl-xL in the past few years.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第25期2871-2876,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30571810~~
