摘要
目的:探讨埃兹蛋白(Ezrin)在非小细胞肺癌(NSCLC)组织中的表达及其意义。方法:利用免疫组织化学(EnVision法)检测72例NSCLC中Ezrin蛋白的表达,分析其与NSCLC临床病理特点及其他指标之间的关系。结果:NSCLC中Ezrin蛋白的表达率为61.1%(44/72),Ezrin高表达与患者有无区域淋巴结转移密切相关(P<0.05),而与患者性别、肿瘤的组织学分型、TNM分期、病理分级和吸烟等无明显相关。生存分析显示Ezrin高表达的患者生存率明显低于Ezrin低表达的患者(P<0.05)。结论:Ezrin表达可能与NSCLC转移相关,其检测可作为判断NSCLC患者预后的一项重要指标。
Objective：To detect the expression of ezrin and its significance in non-small cell lung cancer（NSCLC）. Methods：Ezrin expressions in 72 cases of NSCLC were examined by En Vision method of immunohistochemical staining, and its relation with the clinical pathologic and other characters was analyzed. Results：The high expression rate of ezrin in NSCLC was 61.1% and significantly correlated with lymph node metastasis （ P 〈 0. 05 ）, but not associated with gender, histological subtype,TNM stages, pathologicalgrading and smoking. The Kaplan-Meier survival analysis demonstrated that the survival rate of patients with ezrin overexpression was obviously poorer than the one with ezrin lowexpression. Conclusion：Ezrin expression may be associated with NSCLC metastasis. It may be an important marker to estimate the prognosis of NSCLC patients.
出处
《临床肿瘤学杂志》
CAS
2008年第9期784-787,共4页
Chinese Clinical Oncology
基金
南京军区南京总医院科研基金资助(NZ06006)
关键词
非小细胞肺癌
埃兹蛋白
转移
预后
Non-small cell lung cancer （NSCLC）
Ezrin
Metastasis
Prognosis
