1Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptorαchains( CD25 ) breakdown of signle mechanism of self-tolerance causes various autoimmune disease [ J ]. J Immunol, 1995,155 (3):1151 -1164.
2Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor foxp3 [ J]. Science, 2003,299 (5609) : 1057 - 1061.
3Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells[J]. Nat Rev Immunol, 2003,3(3) :253 -257.
4von Boehmer H. Mechanisms of suppression by suppressor T cells [J]. Nat Immunol, 2005,6(4) :338 -344.
5Nishioka T,Shimizu J, lida R,et al. CIM + CD25 + Foxp3 + T cells and CIM + CD25-Foxp3 + T cells in aged mice[J]. J Im- munol, 2006,176 ( 11 ) :6586 - 6593.
6Lindley S, Dayan CM,Bishop A,et al. Defective suppressor function in CIM + CD25 + T cells from patients with type 1 diabetes [ J]. Diabetes,2005,54( 1 ) :92 - 99.
7Beyer M,Schuhze JL. Regulatory T cells in cancer[ J ]. Blood, 2006,108 (3) :804 -811.
8Zhou G, Levitsky HI. Natural regulatory T cells and de novo-induced regulatory T cells contribute independently to tumor-specific tolerance[ J ]. J Immuno1,2007,178 (4) :2155 - 2162.
9Sharma S, Dominguez AL, Lustgarten J. High accumulation of T regulatory cells prevents the activation of immune responses in aged animals [ J ].J Immunol, 2006,177 ( 12 ) : 8348 - 8355.
10Kilinc MO,Aulakh KS,Nair RE,et al. Reversing tumor immune suppression with intratumoral IL-12: activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8 + T effectors[ J]. J lmmunol,2006,177 (10) :6962 -6973.
4Semba S,Itoh N,Ito M,et al.The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone(LY294002),a specific inhibitor of phosphatidylinositol 3'-kinase,in human colon cancer cells.Clin Cancer Res.2002;8(6):1957-1963.
5Liang J,Ge F,Guo C,et al.Inhibition of PI3K/Akt partially leads to the inhibition of PrP(C)-induced drug resistance in gastric cancer cells.FEBS J.2009;276(3):685-694.
6Hu L,Zaloudek C,Mills GB,et al.In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor(LY294002).Clin Cancer Res.2000;6(3):880-886.
7Fujiwara M,Izuishi K,Sano T,et al.Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells.J Exp Clin Cancer Res.2008;27(1):76.
8Wang J,Yang L,Yang J,et al.Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells.Cancer Rea.2008;68(9):3152-3160.
9Chatila TA.Role of regulatory T cells in human diseases.J Allergy Clin Immunol.2005;116(5):949-959.
10Milojevic D,Nguyen KD,Wara D,et al.Regulatory T cells and their role in rheumatic diseases:a potential target for novel therapeutic development.Pediatr Rheumatol Online J.2008;6:20.