利培酮合并氟西汀对无精神病性症状抑郁症的疗效比较

Comparison of risperidone combined with fluoxetine in treatment of depression without psychotic symptoms

目的观察利培酮合并氟西汀对无精神病性症状抑郁症的疗效和安全性。方法147例无精神病性症状抑郁症患者随机分为研究组(利培酮+氟西汀)72例、对照组(氟西汀)75例,治疗8 wk。于治疗前、治疗后每2 wk测评汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、治疗中需处理的不良反应量表(TESS)。疗效评价以HAMD减分率为标准,不良反应以TESS评分为标准。结果2组HAMD、HAMA评分组间比较从wk 2末开始差异有统计学意义(P<0.05),2组疗效比较差异有统计学意义(P<0.05),各时期TESS评分组间比较差异无统计学意义(P>0.05)。结论利培酮合并氟西汀治疗无精神病性症状抑郁症的疗效和安全性较好。

AIM To compare the efficacy and adverse drug reaction （ADR） of risperidone combined with fluoxetine in patients with depression without psychotic symptoms. METHODS One handred and forty-seven patients with depression without psychotic symptoms were randomly divided into study group（risperidone ＋ fluoxetine, n = 72） and control group（fluoxetine, n = 75） and observed for 8 weeks. All patients were assessed with HAMD, HAMA and TESS. The therapeutic effect was assessed using subtraction rates of HAMD, and drug-related ADR were evaluated by using TESS. RESULTS The significant difference in HAMD and HAMA from 2nd week between two groups was found and significant difference in therapeutic effect was also found, but no significant difference in TESS was found. CONCLUSION Risperidone combined with fluoxetine has better efficacy and safety in treatment for depression without psychotic symptoms.