芬必得胶囊减轻固定矫治器初戴后疼痛的临床观察

Clinical observation of fenbid capsules on releasing pain for patients after first wearing fixed orthodontic appliances

目的探讨芬必得胶囊（Fenbid Capsules，布洛芬缓释胶囊）对固定矫治器患者初戴后疼痛的治疗效果及不良反应。方法用随机、双盲法研究芬必得胶囊对固定矫治器患者初戴后疼痛的的治疗效果，与安慰剂对照。通过改良牙科焦虑量表筛选出128例非牙科焦虑症患者，随机分为芬必得组（实验组）和安慰剂组（对照组），每组64例，通过0～10数字疼痛强度量表对患者7d内的正畸疼痛水平（自发痛、激惹痛）进行评分，对比其治疗效果及不良反应。结果在固定矫治器患者初戴后的2h,6h、1d,2d、3d，实验组的正畸疼痛水平（自发痛、激惹痛）均明显低于对照组，差异有统计学意义（P〈0．05）；在第7d，2组疼痛水平无统计学差异（P〉0．05）；未发现用药不良反应。结论芬必得对固定矫治器患者初戴后疼痛（自发痛、激惹痛）的缓解有较好的临床效果。

Objective To investigate the effect of fenbid capsules（ibuprofen sustained release capsules） on orthodontic pain for the patients with first wearing fixed orthodontic appliances. Methods A randomized, double-blind study was designed. 128 patients with no dental anxi- ety were divided into two groups （64 cases each） with MDAS（modified dental anxiety scale）. Among them, they were randomly divided into two groups： fenbid group（trial group） and placebo group（control group）. The pain（ spontaneous pain, challenge pain） evaluations were made during using a 0 - 10 Numerical Rating Scale （NRS） for 7 d. Results The trial group reported significantly less orthodontic pain（ spontaneous pain,challenge pain） than the control group（ P 〈 0.05） at 2 h,6 h, 1 d,2 d,3 d. There was no difference between the two groups at 7 d（ P 〉 0.05）. No adverse reaction had been found after the treatment of fenbid capsules. Conclusion Administration of fenbid capsules could get good clinical results as a treatment of decreasing orthodontic pain （spontaneous pain, challenge pain） for the patients with no dental anxiety.