3Christopher MC,Susan LD, Melanie KM,et al. Apelin, the ligand for the endothelial G-protein coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo[J]. Developmental Biology, 2006,296(1):177- 189.
7Atsushi K, Norihito S, Maki O, et al. Apelin is a novel angiogenic factor in retinal endothelial cells[J]. Biochemical and Bioph ysical Resea rch Communications, 2004,325 (2) : 395 - 400.
8Bernard M, Natacha M, Marion C, et al. Apelin(65 - 77) activates p70S6 kinase and is mitogenic for umbilical endothelial cells[J]. FASEB, 2004,18(15) : 1 909 - 1 911.
9Ishida J, Tatsuo H, Yasumi H, et al. Regulatory roles for APJ, a seven-transmenbrane receptor related to angiotensin- type 1 receptor in blood pressure in vivo[J]. The Journal of Biological Chemistry, 20(14,297 (25) : 26 274 - 26 279.
6O'CARROLL A M,SELBY T L,PALKOVITS M,et al.Distribution of mRNA encoding B78/apj,the rat homologue of the human APJ receptor,and its endogenous ligand apelin in brain and peripheral tissues[J].Biochim Biophys Acta,2000,1492 (1):72-80.
7MARCOS E,FADEL E,SANCHEZ O,et al.Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension[J].Circ Res,2004,94(9):1263-1270.
8KATUGAMPOLA S D,MAGUIRE J J,MATTHEWSON S R,et al.[125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man[J].Br J Pharmacol,2001,132(6):1255-1260.
9ASHLEY E A,POWERS J,CHEN M,et al.The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo[J].Cardiovasc Res,2005,65(1):73-78.
10SZOKODI I,TAVI P,FOLDES G,et al.Apelin,the novel endogenous ligand of the orphan receptor APJ,regulates cardiac contractility[J].Circ Res,2002,91(5):434-440.
3Reaux-Le Goazigo A,Morinvile A,Burlet A,et al.Dehydration-induced cross-regulation of Apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neurons.Endocrinology,2004,145(9):4392-4400.
4Jaszberenyi M,Bujdoso E,Telegdy G.Behavioral,neuroendocrine and thermoregulatory actions of Apelin-13.Neuroscience,2004,129(3):811-816.
5Horiuchi Y,Fujii T,Kamimura Y,et al.The endogenous,immunologically active peptide Apelin inhibits lymphocytic cholinergic activity during immunological responses.J Neuroimmunol,2003,14(1/2):46-52.
6Esposito V,De Falco M,De Luca L,et al.Immunohistochemical study of Apelin,the natural ligand of receptor APJ,in a case of AIDS-related cachexia.In Vivo,2002,16(5):337-340.
7Choc W,Albright A,Sulcove J,et al.Functional expression of the seven-transmembrane HIV-l co-receptor APJ in neural cells.J Neurovirol,2000,(6 Suppl 1):S61-S69.
8Wang G,Anini Y,Wei W,et al.Apelin,a new enteric peptide:localization in the gastrointestinal tract,ontogeny,and stimulation of gastric cell proliferation and of cholecystokinin secretion.Endocrinology,2004,145(3):1342-1348.
9Principe A,Melgar-Lesmes P,Fernández-Varo G,et al.The Hepatic Apelin System:A New Therapeutic Target for Liver Disease.HEPATOLOGY,2008,48(4):1193-1201.
10Xie H,Tang SY,Cui RR,et al.Apelin and its receptor are expressed in human osteoblasts.Regul Pept,2006,134(2-3):118-125.