高尿酸血症与心血管疾病相关危险因素关系调查分析

A Study on the Relationship between Serum Uric Acid and the Related Risk Factors of Cardiovascular Diseases

目的探讨血尿酸水平与心血管疾病相关危险因素的关系。方法对2007年8～9月间在我院进行干部体检的380例体检者的身高、体重、体质指数、收缩压、舒张压进行测量,并检测其血液生化指标,包括血尿酸(UA)、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDLCH)、低密度脂蛋白-胆固醇(LDHCH)、75g葡萄糖负荷后2h血糖(2hPG)。结果本组高尿酸血症患病率为47.1%。高尿酸血症者具有高BMI、高TG、高血压及低HDLCH,差异有统计学意义(P<0.01)。线性相关分析显示,血尿酸浓度与BMI、血TG、SBP及DBP呈正相关,与HDLCH呈负相关,差异有统计学意义(P<0.001)。偏相关分析显示,在排除其他影响因素后血尿酸浓度仍与BMI及DBP呈正相关(P<0.001)。结论高尿酸是肥胖、高血压的独立危险因素。

Objective To explore the relationship between serum uric acid and the related risk factors of cardiovascular diseases. Methods The blood samples were collected from 380 individuals who were performing health examination including the measurement of the body heights, weights, body mass index（BMl）, systolic blood pressure （SBP）, diastolic blood pressure（DBP）, at the same time, measured serum uric acid（SUA）, the fasting blood glucose （FBG）, serum triglyceride （TG）, serum total cholesterol （TC）, serum high density lipoprotein cholesterol （HDLCH）, serum low density lipoproteincholesterol （LDLCH）, and 2-hour postprandial blood glucose （2hPG） of oral glucose tolerance tests as well as biochemistry targets from August to September 2007 in our hospital. Results The prevalence of hyperuricemia peoples in this group was 47.1%. Hyperurieemia peoples had high body mass index （BMI）, high TG, hypertension, and low HDLCH, showing significant differences （P〈0.01） when compared with those without hyperuricemia. The results of linear correlation analysis revealed that serum uric acid concentration was in a positive correlation with BMI, serum TG, SBP, and DBP, while in a negative correlation with HDLCH （P〈0.001）. Partial correlation analysis showed that serum uric acid concentration was also in a positive correlation with BMI and DBP except other effective factors （P〈0.001）. Conclusion Hyperuricemia was an independent risk factor of obesity and hypertension.