桃儿七的抗肿瘤作用

The Antitumour Activity of Sinopodophyllum emodi

桃儿七根及根茎的乙醇提取物对体外培养的人红白血病K_(562)细胞、小鼠白血病L_(1210)细胞及L_(7712)细胞,用小孔板法,10.0、5.0、2.5及1.0μg/ml终浓度剂量,24h后残留率分别为44.17％、47.63％、64.43％、79.57％,42.84％、50.73％、63.21％、75.10％及39.76％、46.36％、61.42％、75.24％;该药品小鼠单次腹腔注射LD_(50)为76.3～60.6mg/kg;对小鼠移植性肿瘤EAC、U_(14)及H_C,该药品用14.0mg/kg及7.0mg/kg剂量,瘤重抑制率分别为42.2％、37.8％,38.8％、33.3％及41.5％、35.6％。

This paper has shown the cytocidal effects of alcohol extracts of roots and rhizomes of Sinopodophyllum emodi (Wall. ) Ying on human erythroleukemia K562 cells, leukemia L1210 cells, leukemia L7712 cells in vitro,using microculture method for 24 hours. The survival rates on K562cells in the final concentrations of 10. 0, 5. 0, 2. 5, 1.0 μg/ml of the extracts of Sinopodophyllum emodi (WAll. ) Ying were 44. 17%, 47. 63% , 64. 43% , 79. 57% respectively. The survival rates on L1210 and L7712 cells were 42. 84% , 50. 73% , 63. 21% , 75. 10% and 39. 76% , 46. 36% , 61. 42% , 75. 24% respectively. LD50 of the extracts singly i. p. in mice was 76. 3-60. 6mg/kg. In vivo, the growth of transplanted mouse tumours (EAC, U14 and Hc) was inhibited by the extracts of Sinopodophyllum emodi (Wall. ) Ying with inhibitory rates 42. 2% , 38. 8% , 41. 5% (14. 0mg/kg); 37. 8% , 33. 3% , 35.6% (7. 0mg/kg) .