肾衰合剂对慢性肾衰患者整体功能代偿及生活质量影响的临床研究

Effect of Shenshuai Mixture on Compensation of Whole Function and Quality of Life in Patients with Chronic Renal Failure

目的:观察肾衰合剂对慢性肾衰患者的整体功能代偿及生活质量的影响。方法:将138例随机分为2组,每组69例。对照组以西药常规治疗;治疗组在对照组治疗基础上加用肾衰合剂治疗。观察2组治疗前后的血清血肌酐(Scr)、内生肌酐清除率(Ccr)、C反应蛋白(CRP)及白介素-6(IL-6)及生活质量的改变。结果:总有效率治疗组88.31%,对照组59.97%,2组比较,差异有非常显著性意义(P<0.01)。2组治疗后Scr、CRP、IL-6、Ccr均有显著改善,与治疗前比较,差异有显著性或非常显著性意义(P<0.05,P<0.01);2组治疗后Scr、CRP、IL-6、Ccr比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。治疗后2组生活质量比较,差异有显著性意义(P<0.05)。结论:肾衰合剂能促进慢性肾衰患者整体功能代偿及生活质量的改善。

Objective:To observe the therapeutic effect of Shenshuai Granules (SM)on compensation of whale function and quality of life(QOL)in patients with chronic renal failure(CRF).Methods:One hundred and thirty-eight CRF patients were equally randomized into two groups:the control group(n=69)received routine western medicine,and the treatment group(n=69)received SM and routine western medicine.The changes of serum creatinine rate(SCR),endogenous creatinine clear- ance rate(CCR),C-reactive protein(CRP)and interleukin-6(IL-6)as well as QOL were observed in the two groups before and after treatment.Results:The total effective rate was 88.31% in the treatment group and 59.97% in the control group, the difference being significant(P<0.01).The serum levels of SCR,CRP,IL-6 and CCR were improved in the two groups after treatment(P<0.05 or P<0.01 as compared with those before treatment),and the differences of the above parameters as well as QOL in the two groups after treatment were also significant in the two groups after treatment(P<0.05 or P<0.01).Conclusion:SM can promote the compen- sation of whole function and improve the QOL in patients with CRF.