摘要
目的:观察莪棱胶囊防治子宫内膜异位囊肿复发的临床疗效。方法:将66例患者随机分为2组各33例,治疗组经腹腔镜或剖腹行内膜异位囊肿保守性手术,术前3月、术后7天应用莪棱胶囊治疗;对照组经腹腔镜或剖腹行内膜异位囊肿保守性手术,术前不用药,术后7天开始服用丹哪唑胶囊。结果:术后1年治疗组复发1例,对照组复发6例,2组比较,差异有显著性意义(P<0.05)。术后1年2组患者痛经程度改善比较,差异有显著性意义(P<0.05),治疗组疗效优于对照组。治疗后2组血清E_2、P、PRL水平均明显改善(P<0.05,P<0.01);治疗组对血清E_2、PRL值的改善效果较对照组更为显著(P<0.05)。治疗后2组血液流变学指标红细胞聚集指数、红细胞压积、血浆黏稠度、纤维蛋白原、全血高切、全血中切、全血低切等均有不同程度改善(P<0.05,P<0.01)。结论:莪棱胶囊可改善子宫内膜异位囊肿患者症状、降低囊肿近期复发率,其机制可能通过对患者的血流状态和性激素水平的调节达到治疗作用。
Objective:To observe the therapeutic effect of Eleng Capsule(EC) for the prevention and treatment of cyst recurrence in patients with endometriosis(EM) Methods:Sixty-six EM patients with cyst recurrence were equally randomized into two groups.Both of the two groups received conservative surgery for endometrial cyst through laparoscopy or laparotomy.The control group received danazol Capsules 7 days after operation,and the treatment group received EC 3 months before operation and 7 days after operation.Results:The follow-up results showed that recurrence was found in one patient of the treatment group,and 6 patients in the control group one year after operation,the difference being significant(P<0.05));dysmenorrheal was relieved in the two groups and the effect in the treatment group was superior to that in the control group(P<0.05).After treatment,serum estradiol,progesterone and prulactin levels were much improved in the two groups(P<0.05 or P<0.01),and the effect in the treatment group was superior to that in the control group (P<0.05).Hemorheological parameters such as red blood cell aggregation index, hematocrit(HCT),plasma viscosity,plasma fibrinogen,and high-,middle-and low-shear whole blood viscosity were also improved in the two groups(P<0.05 or P<0.01).Conclusion:EC can relieve the symptoms of endometrial cyst patients, and decrease the short-term recurrence rate of cyst,and its mechanism may be relat- ed with the regulation of blood flow and sexual hormone levels in EM patients.
出处
《新中医》
CAS
北大核心
2008年第10期63-64,共2页
New Chinese Medicine
基金
广州中医药大学整体规划课题(编号:GH0225)
