胰岛素不同部位皮下注射对2型糖尿病患者血糖漂移的影响

Effects of the different hypodermic injection site of insulin on blood glucose fluctuations in type 2 diabetic patients

目的观察胰岛素皮下注射部位不同的2型糖尿病患者血糖水平的漂移变化。方法30例2型糖尿病患者随机分为三组：腹部皮下注射组（A组，10例）、臂部三角肌皮下注射组（B组，10例）和股外侧皮下注射组（C组，10例）。胰岛素强化治疗半个月后，动态血糖监测系统进行连续（71±10）h血糖监测，动态血糖监测数值（847±80）个。结果三组患者平均血糖水平差异无统计学意义，但腹部皮下注射组日内血糖最高值、日内血糖漂移最大幅度均显著低于其他两组患者（P〈0．05）；腹部皮下注射组日内血糖最低值和血糖漂移于3．6～10．0mmol／L所占的日内时间百分比高于其他两组患者（P〈0．05）。结论胰岛素皮下注射部位的选择对2型糖尿病患者血糖漂移水平有明显影响，以腹部皮下注射组血糖漂移幅度最小。

Objective To observe the fluctuations of blood glucose in type 2 diabetic patients treated by insulin hypodermic injection in different sites. Methods 30 patients with type 2 diabetes were randomly divided into three groups：abdominal, edltoid region and lateral femoral subcutaneous injection group. After half a year of insulin therapy, dynamic glucose monitoring for consecutive （71 ± 10） hours was conducted, and （847 ± 80 ） results of glucose level were obtained. Results The average glucose had no difference in three group, but diurnal maximum and maximum fluctuation amplitude in patients of abdominal subcutaneous injection group were significantly lower than the other groups（P 〈 0.05 ）. The time percentage of glycemic fluctuations within 3.6 - 10.0mmol/L and diurnal /ninimum was higher compared to other groups（ P 〈 0.05）. Conclusion The site choice of insulin subcutaneous injection can influence the fluctuations of blood glucose in type 2 diabetes mellitus and abdominal subcutaneous tissue was the most ideal of the three subcutaneous injection sites.