摘要
目的探讨眼镜蛇毒对大鼠延髓nNOS表达的影响。方法采用免疫组织化学方法,观察并比较nNOS阳性神经元在眼镜蛇毒组、生理盐水组、正常对照组大鼠延髓的表达。结果眼镜蛇毒组大鼠延髓外侧网状核nNOS阳性神经元明显多于生理盐水组和正常对照组(P<0.01),细胞平均灰度值明显降低(P<0.01)。结论眼镜蛇毒对大鼠延髓nNOS表达有上调作用。
Objective To investigate the effects of Naja naja atra venom on the expression of nNOS in medulla oblongata of rat. Methods The methods of immunohistochemistry technique were used to observe the different expression of nNOS positive nerve cells in Naja naja atra venom group, saline group and control group. Results The number of nNOS positive nerve ceils in nucleus reticularis lateralis of Naja naja atra venom group were higher markedly than that of saline and control groups（P〈0. 01） ,cellular average optical density value lowered strikingly（P〈0.01）. Conclusion Naja naja atra venom could increase the expression of nNOS in medulla oblongata of rats.
出处
《蛇志》
2008年第3期169-171,176,共4页
Journal of Snake
基金
皖南医学院中青年科研基金(项目编号:WK200706)
关键词
眼镜蛇毒
延髓
nNOS大鼠
Naja naja atra venom
Medulla oblongata
nNOS
Rat
