NK细胞与荨麻疹发病机制

Role of NK Cell in the Pathogenesis of Urticaria

目的探讨 NK 细胞与荨麻疹发病机制的关系。方法用流式细胞仪检测急、慢性荨麻疹患者和健康献血者外周血 NK 细胞构成比,并分析 NK 细胞与急、慢性荨麻疹患者的病情、病程、抗组胺治疗效果等方面的关系。结果慢性荨麻疹患者 NK 细胞构成比升高,与健康对照组比较差异具有显著性(P<0.05),急性者 NK 细胞构成比升高,但与健康对照组比较差异无显著性;抗组胺治疗效果差的急、慢性荨麻疹患者 NK 细胞构成比显著增高(P<0.05,P<0.01);NK 细胞构成比与急、慢性荨麻疹的症状评分和病程及既往发作情况无相关性。结论荨麻疹患者存在 NK 细胞构成比紊乱现象.其作用点可能发生在对抗抗组胺药上。

Objective To study the role of NK cell in the pathogenesis the patients with urticaria. Methods NK cell of the peripheral blood in 32 patients with acute urticaria and 54 patients with chronic urticaria and 30 sex and age matched healthy controls were assayed by flow cytometry. Moreover, the symptom, course, anti-histamine-resistant of the patients with urticaria were assessed. Results The percentage of NK cell was significant higher in the patients with chronic urticaria than that in the control group （P 〈 0.05）, but not in the patients with acute urticaria. The percentage of NK cell was significant increased in anti-histamineresistant of the patients with urticaria. The percentage of NK cell of the patients with urticaria was not correlation to the symptom scores, the courses and the previous history of the patients with urticaria. Conclusions There was immunologic dysfunction of NK cell of the peripheral blood in the patients with urticaria. And it may play a important role in the mechanism of anti-histamine-resistant in the patients with urticaria.