摘要
目的:探讨基质金属蛋白酶-2(MMP-2)和膜型MMP(MT1-MMP)及其组织抑制剂TIMP-2与输卵管妊娠的关系。方法:运用免疫组化结合病理图像半定量分析方法,检测32例正常输卵管壶腹部标本(A组)、32例输卵管炎壶腹部标本(B组)、26例输卵管壶腹部妊娠标本(C组)中MT1-MMP、MMP-2及TIMP-2的表达情况。结果:TIMP-2在A组输卵管黏膜中表达最高,与B组、C组比有统计学差异,B、C组间比较无差异。MMP-2,MT1-MMP表达强度与TIMP-2相反,A组最低,B组的表达最高,C组的表达略低于B组,组间两两比较均有统计学差异(P<0.05)。结论:输卵管的慢性炎症会引起MMP-2的激动剂MT1-MMP表达增强,MMP-2/TIMP-2之间的动态平衡失衡,从而可能参与了输卵管妊娠的发生。
Objective： To explore MMP-2, MT1-MMP, TIMP-2 possible mechanisms in tubal pregnancy. Methods： Ampulla of 32 normal fallopian tube （group A）, 32 chronic salpingitis （group B）, and 26 tubal pregnancy （group C） were selected. Immunohistochemistry and semi-quantity pathologic image software system were used to analyze the expression of MMP-2, MT1-MMP, TIMP-2, respectively. Results： No significant difference was found for TIMP-2 expression between group B and group C （P〉0.05）, while it was higher in group A than that in group B or group C （P〉0.05）; significant difference was found for MMP-2 and MT1-MMP expression among three groups, respectively （P〈0.05）; significant difference was found for TIMP-2 expression between group A and B （P〈0.05）. Conclusion： The higher expression of MT1-MMP, imbalanced expression of MMP-2/TIMP-2 probably participated in the formation of tubal pregnancy through chronic inflammation of fallopian tube.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2008年第9期530-534,共5页
Reproduction and Contraception
