同期体外受精-胚胎移植(IVF-ET)赠卵的临床应用

Clinical Application of Donated Oocyte from Infertile Donors during IVF-ET

目的:探讨当前形势下中国赠卵的可行性、赠卵数、影响因素及存在的问题。方法:行IVF-ET并自愿捐卵的21例患者及同期接受赠卵并完成IVF-ET周期的23例患者,分析供、受双方的受精率、妊娠率和种植率。结果:23例患者共接受赠卵135枚,平均每周期接受卵子5.6±1.5枚,29个移植周期,12例妊娠,周期妊娠率为41.4%。供卵的21例患者,9个新鲜胚胎移植周期,2例妊娠;32个解冻胚胎移植周期,12例妊娠,冷冻移植周期的妊娠率为37.5%。供、受双方受精率、冷冻胚胎移植周期的妊娠率、累积妊娠率均无统计学差异(P>0.05)。结论:供卵者提供6个左右的卵子既不影响供卵者的妊娠,也能为受卵者提供一个良好的妊娠机会。

Objective： To explore the feasibility, the number of oocyte donated, effected factors and existence condition of oocyte donation during IVF-ET in China. Methods： Twenty-one patients undergoing IVF-ET shared their oocytes with 23 patients of oocyte recipients, their pregnancy rate, fertilization rate and implantation rate were analyzed. Results： Of 23 oocyte recipients of 29 transfer cycles, the number of sharing oocyte was 5.6 _＋ 1.5, 12 patients got pregnancy. Of 21 donors of 9 fresh ET cycles, 2 patients got pregnancy, and of 19 donors of 32 thaw-frozen transfer cycles, 12 patients got pregnancy. There was no significant difference in fertilization rate, pregnancy rate per thaw-frozen embryo transfer and clinical pregnancy rate. Conclusion： Donors provide about 6 ovum to the oocyte recipients, not only influenced the pregnancy rate of donor, but also provide the good pregnancy chance with the oocyte recipients.