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心力衰竭中的炎症反应及胆碱能抗炎通路的研究进展 被引量：1

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摘要 炎症在心血管疾病发生发展中起着重要的作用。越来越多的研究表明,心力衰竭(HF)是一种炎症性疾病,抗炎将是HF治疗中极有希望的一种治疗措施。心血管疾病与胆碱能神经活性有着密切的关系,近年来研究表明,胆碱能抗炎通路(CAP)能够反馈性监测、调整炎症反应。本文主要从HF和炎症以及CAP在临床治疗HF中的应用前景作一综述。
作者 孔珊珊 臧伟进
机构地区 西安交通大学医学院心血管生理药理研究室
出处 《心脏杂志》 CAS 2008年第5期630-633,共4页 Chinese Heart Journal
基金 国家重点基础研究发展计划(973)项目资助(2007CB512005) 国家自然科学基金项目资助(30770785) 教育部高等学校科技创新工程重大项目培育基金资助(705045) 教育部高校博士点基金资助(20050698012)
关键词 胆碱能抗炎通路 迷走神经 α7亚基 心力衰竭 炎症
分类号 Q463 [生物学—生理学] R96 [医药卫生—药理学]
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参考文献17

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同被引文献23

  • 1Zhang Y,Mazgalev TN.Arrhythmias and vagus nerve stimulation[J].Heart Fail Rev,2011,16(2):147-161.
  • 2Uemura K,Zheng C,Li M,et al.Early short-term vagal nerve stimulation attenuates cardiac remodeling after reperfused myocardial infarction[J].J Card Fail,2010,16(8):689-699.
  • 3Esco MR,Olson MS,Williford HN,et al.The relationship between resting heart rate variability and heart rate recovery[J].Clin Auton Res,2010,20(1):33-38.
  • 4Chapleau MW,Sabharwal R.Methods of assessing vagus nerve ac-tivity and reflexes[J].Heart Fail Rev,2011,16(2):109-127.
  • 5Tang YD,Dewland TA,Wencker D,et al.Post-exercise heart rate recovery independently predicts mortality risk in patients with chron-ic heart failure[J].J Card Fail,2009,15(10):850-855.
  • 6Guazzi M,Arena R,Pinkstaff S,et al.Six months of Sildenafil therapy improves heart rate recovery in patients with heart failure[J].Int J Cardiol,2009,136(3):341-343.
  • 7Abramochkin DV,Nurullin LF,Borodinova AA,et al.Non-quantal release of acetylcholine from parasympathetic nerve terminals in the right atrium of rats[J].Exp Physiol,2010,95(2):265-273.
  • 8Sabbah HN,Ilsar I,Zaretsky A,et al.Vagus nerve stimulation in experimental heart failure[J].Heart Fail Rev,2011,16(2):171-178.
  • 9De Ferrari GM,Crijns HJ,Borggrefe M,et al.Chronic vagus nerve stimulation:a new and promising therapeutic approach for chronic heart failure[J].Eur Heart J,2011,32(7):847-855.
  • 10Katare RG,Ando M,Kakinuma Y,et al.Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mito-chondrial permeability transition pore independent of the bradycardi-ac effect[J].J Thorac Cardiovasc Surg,2009,137(1):223-231.

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心脏杂志
2008年 第5期

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