期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Ⅱ型肝素诱导的血小板减少症患者血清HIT抗体检测的临床意义 被引量：7

原文传递
导出
摘要 Ⅱ型肝素诱导的血小板减少症（HIT，Heparin—induced thrombocytopenia）是应用肝素的严重并发症，这些患者很少发生出血，却可能发生广泛的动脉、静脉血栓，称为肝素诱导的血小板减少伴血栓形成综合征（HITTS，Heparin—induced thrombocytopenia with thrombosis syndrome），后果严重，死亡率达50％。因此，早期诊断至关重要，但目前国内只有少数病例报道，尚无HIT实验诊断标准及相关研究。我们采用ELISA法检测HIT抗体，初筛HIT患者，监测应用肝素患者HIT的发生，为肝素的临床应用提供依据。
作者 王京华 车德海 谢蕊 王宏梅 刘娟
机构地区 哈尔滨医科大学附属第二医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2008年第9期633-634,共2页 Chinese Journal of Hematology
基金 黑龙江省科技攻关项目（GC05C40501） 志谢：感谢加拿大卡尔加里大学Manchiu Poon教授赠予的HIT阳性及阴性对照血清,同时感谢该大学赵滨生老师提供的技术指导
关键词 血小板减少症 肝素诱导 HIT 临床意义 抗体检测 Ⅱ型 HEPARIN ELISA法检测
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献10

  • 1Gurbuz AT, Elliott WG, Zia AA. Heparin-induced thrombocytopenia in the cardiovascular patient: diagnostic and treatment guidelines. Eur J Cardiothorac Surg, 2005, 27:138-149.
  • 2Davidson SJ, Wadham P, Rogers L, et al. Endothelial cell damage in heparin-induced thrombocytopenia. Blood Coagul Fibrinolysis, 2007, 18:317-320.
  • 3Greinacher A, Amiral J, Dummel V, et al. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggrcation test, heparin-induced pletelct activation test, and platclet factor 4/ heparin enzyme-linked immunosorbent assay. Transfusion, 1994, 34:381-385.
  • 4Rice L. Heparin-induced thrombocytopenia: myths and misconceptions (that will cause trouble for you and your patient). Arch Intern Med, 2004, 164:1961-1964.
  • 5Castelli R, Cassimerio E, Cappellini MD, et al. Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects. Cardiovasc Hematol Disord Drug Targets, 2007, 7: 153-162.
  • 6Warkentin TE. Platelet count monitoring and laboratory testing for heparin-induced thrombocytopenia. Arch Pathol Lab Med, 2002, 126: 1415-1423.
  • 7Tsirigotis P, Mantzios G, Makris F, et al. Bilateral renal artery thrombosis due to heparin-induced thrombocytopenia-thrombosis syndrome. Successful treatment with longterm application of lepirudin. Ulster Med J, 2006, 75: 88-90.
  • 8Amiral J. Antigents involved in heparin-induced thrombocytopenia. Semin Hematol, 1999, 36 : 7-11.
  • 9Chong BH. Heparin-induced thrombocytopenia. J Thromb Haemost, 2003, 1: 1471-1478.
  • 10Chan M, Malynm E, Shaz B, et al. Utility of consecutive repeat HIT ELISA testing for heparin-induced thrombocytopenia. Am J Hematol, 2008, 83: 212-217.

同被引文献73

  • 1季闽春,钱庆庆,杨耀芳.肝素诱导的血小板减少症的病因、诊断和治疗研究进展[J].中国临床药理学杂志,2007,23(6):461-465. 被引量：21
  • 2Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest, 2004, 126(3 Suppl) :311S-337S.
  • 3Greinaeher A, Michels I, Kiefel V, et al. A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb Haemost, 1991, 66:734-736.
  • 4Greinacher A, Amiral J, Dummel V, et al. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay. Transfusion, 1994, 34:381-385.
  • 5Price EA, Hayward CP, Moffat KA, et al. Laboratory testing for heparin-induced thrombocytopenia is inconsistent in North America: a survey of North American specialized coagulation laboratoties. Thromb Haemost, 2007,98:1357-1361.
  • 6Savi P, Chong BH, Grenacher A, et al. Effect of fondaparinux on platelet activation in the presence of heparin-dependent antibodies : a blinded comparative multicenter study with unfractionated heparin. Blood, 2005, 105:139-144.
  • 7Warkentin TE. New approaches to the diagnosis of heparin-induced thrombocytopenia. Chest, 2005, 127(2 Suppl) :35S-45S.
  • 8Warkentin TE.An overview of the heparin-induced thrombocytopenia syndrome[J],Semin Thromb Hemost, 2004 : 30: 273- 283.
  • 9Massimo Franchini.Heparin-induced thrombocytopenia:a update[J].Thromb J ,2005,3 : 14.
  • 10Alberio, Lorenzo.Heparin -induced thrombocytopenia: some working hypotheses on pathogenesis,diagnostic strategies and treatment [J].Hemostasis and thrombosis,2008,15 (5):456- 464.

引证文献7

二级引证文献95

中华血液学杂志
2008年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部