糖尿病牙周炎病人龈沟液TNF-α水平及其与HbA1c的相关性分析

Correlation analysis between level of TNF-α in gingival crevicular fluid and glycosylated hemoglobin in diabetes mellitus paticnt with periodonitis

目的:研究依赖胰岛素治疗的糖尿病(IDDM)伴牙周炎病人、单纯牙周炎病人和牙周健康者龈沟液(gingival cervicular fluid,GCF)TNF-α水平及其与糖代谢状况的关系。方法:用ELISA法检测GCF中TNF-α的水平,同时检测受试者的糖化血红蛋白(HbA1c)百分比。结果:IDDM牙周炎组病人GCF中TNF-α水平明显高于单纯牙周炎组及对照组。GCF中TNF-α水平与反映糖代谢控制状况的糖化血红蛋白无相关性。结论:糖尿病可使牙周炎病人龈沟液TNF-α水平显著增高。

AIM： To investigate the level of tumor necrosis factor - alpha （ TNF - α） in gingival crevicular fluid （GCF） from insulin dependent diabetes mellitus paticnt with periodontitis, simplex periodontitis and periodontal health person, and the relationship between TNF - α concentration and metabolic condition. METHODS ： The level of TNF-α in GCF was measured by ELISA. The concentration of HbAlc in IDDM patients was analyzed. RESULTS： The level of TNF - α in GCF from insulin dependent diabetes mellitus paticnt with periodontitis was significantly higher than that from simplex periodontitis and the control group. The level of TNF-α in GCF was irrelevant to HbA1c was irrelevaht. CONCLUSION： Diabetes can promote the level of TNF-α in GCF from periodontitis.