直肠腔内线圈单体素1H-MRS对前列腺病变的定性诊断价值

Value of single voxel 1H MRS with endorectal coil in prostatic diseases

目的对前列腺癌(PCa)和良性前列腺增生(BPH)的波谱代谢特点进行对比研究,初步评价直肠腔内线圈单体素1H-MRS在前列腺病变定性诊断中的价值。方法对48例前列腺病变患者进行直肠腔内线圈单体素1H-MRS检测,测量波谱代谢产物(胆碱+肌酸)/枸橼酸盐[(Choline+Creatine)/Citrate,Cho+Cre/Cit]的比值。结果最终经手术或穿刺活检病理学证实BPH32例,PCa16例,BPH和PCa患者Cho+Cre/Cit比值分别为0.58±0.28、2.60±1.88(F=24.84,P=0.000)。结论BPH和PCa的波谱代谢物比值差异显著,单体素1H-MRS有助于前列腺病变的定性诊断。

Objective To compare the metabolic characteristics of MRS in prostate cancer （PCa） and benign prostatic hyperplasia （BPH）, and to assess the value of single voxel 1H MRS with endorectal coil in prostatic diseases initially. Methods Single voxel 1H MRS with endorectal coil was performed on 48 patients suffered from prostatic diseases, and MRS metabolites ratio of （Choline＋Creatine）/Citrate （Cho＋Cre/Cit） was measured. Results There were 32 cases of BPH and 16 cases of PCa which were confirmed pathologically through surgery or biopsy. The ratio of Cho＋Cre/Cit in patients with BPH and PCa was 0.58± 0.28 and 2.60±1.88 respectively （t test, F= 24.84, P = 0. 000）. Conclusion Significant difference exists in the ratio of Cho＋Cre/Cit between patients with BPH and PCa. Single voxel 1H MRS contributes to the qualitative diagnosis of prostate diseases.