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多聚ADP核糖聚合酶1Va1762Ala基因多态性与胃癌易感性的关系

Polymorphisms Val762Ala in PARP-1 and gastric cancer
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摘要 目的研究多聚ADP核糖聚合酶1(PARP-1)的Va1762Ala(T2444C)在中国西北甘肃地区汉族人群胃癌患者和健康对照者中的基因型分布频率,并探讨其与胃癌发病风险的关系。方法采用PCR-限制性片段长度多态性方法,对138例胃癌患者和110例健康体检者(排除肿瘤和消化系统疾病)进行病例-对照的基因分型研究。以logistic回归和X^2检验计算比值比(OR)及其95%可信区间(CI)。结果Va1762Ala(T2444C)的Ala等位基因的分布频率在胃癌组(11.5%)明显高于对照组(4.5%),OR值为3.012(95%CI:1.054~8.603,P=0.033)。结论PARP-1 Va1762Ala(T2444C)遗传变异与胃癌易感性相关,PARP-1762Ala等位基因型(2444CC)是胃癌的一个易感性标志。 Objective To investigate the frequency distribution of Val762Ala (T2444C) polymorphism among Han Chinese population in Gansu province, and to explore its relation to the susceptibility to gastric cancer. Methods A hospital-based, case-control study was performed involving 138 patients with gastric cancer and 110 healthy controls by PCR-RFLP method. Logistic regression and Chisquare analyses were used to assess OR and 95% CI. Results PARP-1762Ala allele was overexpressed in gastric cancer cases (11.5 % ) compared with controls (4. 5% ) (OR = 3. 012, 95% CI 1. 054 - 8. 603, P = 0. 033). Statistic analysis showed increased risk for gastric cancer patients with the 762Ala allele. Conclusion PARP-1 Val762Ala (T2444C) is related to the risk of gastric cancer, PARP-1762Ala allele could be used as a susceptibility marker for the development of gastric cancer.
出处 《中华普通外科杂志》 CSCD 北大核心 2008年第9期706-709,共4页 Chinese Journal of General Surgery
关键词 胃肿瘤 多态性 限制性片段长度 聚腺苷二磷酸核糖聚合酶类 疾病遗传易感性 Stomach neoplasms Polymorphism, restriction fragment length Poly ( ADPribose) polymerases Genetic predisposition to disease
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